Gang Cao

U-Probe is a universal probe design platform that enables agentic, AI-assisted creation of FISH probes for spatial-omics applications, validated across multiple scenarios.

This study uses SPIDER-Seq to create a spatial multi-omic atlas of mouse prefrontal cortex, revealing modular organization and neural transmission mechanisms.

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

The paper develops MiP-Seq, a multiomics in situ sequencing method, to analyze spatial gene profiles, mutations, and RNA modifications at single-cell resolution.

CoolBox is a flexible open-source toolkit for visualizing genomics data, compatible with Python, offering customization and integration with Jupyter and web browsers.

The paper characterizes bumblebee genomes across 17 species to identify genetic variation linked to ecological and behavioral traits, revealing insights into genome structure, evolution, and adaptation.

The paper introduces DLO Hi-C Tool for analyzing DLO Hi-C data, providing a pipeline from raw reads to contact maps with quality controls and efficient processing.

The paper develops a multi-fluorescent rabies virus tracing tool to map corticothalamic projection neuron subsets in the primary visual cortex, revealing their layer-specific distribution and multi-target connectivity.

This study creates the first single-cell brain atlas of domestic pigs, identifies cell types and their spatial distribution, and compares them with other species to reveal evolutionary and disease-related insights.