Author
University of TorontoORCID 0000-0003-2428-0759Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, Spencer A. Freeman
This study identifies TMEM63A as a mechanosensitive channel in lysosomes that relieves membrane tension by expelling cations and osmoticants, preventing rupture and cell death.
Ava A Kavianpour, Sina Ghasempour, Kirsten J. Meyer…·Spencer A. Freeman
This study identifies phosphatidylethanolamine (PE) as a phagocytic ligand recognized by CD300 receptors, facilitating the uptake of apoptotic cells and microbial extracellular vesicles.
Jazlyn P. Borges, Yongqian Wang, Liron David…·Benjamin Ethan Steinberg
The paper identifies calcium-driven lipid scrambling as the mechanism activating NINJ1-mediated plasma membrane rupture during lytic cell death.