Cell BiologyThe Journal of Cell BiologyPeer-reviewed
Mechanoresilience of lysosomes conferred by TMEM63A
Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, Spencer A. Freeman
This study identifies TMEM63A as a mechanosensitive channel in lysosomes that relieves membrane tension by expelling cations and osmoticants, preventing rupture and cell death.
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