Javier Martin Gonzalez

Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation

The paper uses pulsed-SILAC in single mouse embryos to study protein synthesis dynamics and phosphosite regulation during early embryogenesis, revealing active maternal proteome synthesis and post-translational regulation.

Male obesity causes adipose mitochondrial dysfunction in F1 progeny via a let-7-DICER axis.

This study shows that male obesity affects adipose mitochondrial function in offspring via the let-7-DICER axis, with reversible effects observed in both mice and human semen.

Sex-Specific DNA-Replication In The Early Mammalian Embryo

The paper investigates DNA replication timing in mouse zygotes and 2-cell embryos, revealing an asynchronous replication program in 2-cell embryos that differs from embryonic stem cells.