Maico Y. Lechner

The paper uses pulsed-SILAC in single mouse embryos to study protein synthesis dynamics and phosphosite regulation during early embryogenesis, revealing active maternal proteome synthesis and post-translational regulation.

This study compares three LysC homologues for proteomics, finding A. lyticus LysC provides better peptide identification and digestion efficiency than others.

This paper develops a high-sensitivity single-cell proteomics platform and applies it to analyze small immune cells, achieving deep proteome coverage and identifying key markers in PBMCs.

The paper performs single-cell proteomics on pancreatic islets from healthy and T1DM donors, identifying cell type-specific differences and donor-specific features.

This study introduces SC-pSILAC, a method to measure protein abundance and turnover in single cells, revealing differentiation-specific dynamics and cell-type markers in human iPSCs.

This study improves single-cell proteomics by increasing protein identification from ~2000 to over 5000 per cell and enhancing throughput and reliability.