Staci A. Sorensen

Neocortical long-range inhibition promotes cortical synchrony and sleep

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

Connecting single neuron transcriptomes to the projectome in mouse visual cortex

The paper integrates transcriptomic, morphological, and electrophysiological data to define neuron types in mouse visual cortex and predict their projection targets.

Multimodal characterization of variation in neuronal types in the mouse basal ganglia

This study uses multimodal Patch-seq data to show that gene expression gradients in mouse basal ganglia neurons correlate with spatial location, physiology, and morphology.

The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits

The paper reveals the external globus pallidus (GPe) as a basal ganglia output hub with distinct subpopulations that mediate specific behaviors through projection-specific circuits.

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum

The paper analyzes multi-modal Patch-seq data from macaque striatum to reveal morphoelectric diversity and functional specialization of neuronal cell types, highlighting primate-specific features and differences from rodents.

Cross-species consensus atlas of the primate basal ganglia

The paper creates a cross-species consensus atlas of primate basal ganglia cell types using multiomic data from human, macaque, and marmoset, identifying 61 conserved cell types and a novel hybrid medium spiny neuron type.

The ANTsX Ecosystem for Mapping the Mouse Brain

The paper demonstrates the use of ANTsX for precise spatial mapping of the mouse brain using standardized coordinate systems and presents novel workflows for longitudinal trajectory analysis and automated morphological measurements.

Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level

This study integrates molecular and morphological data to classify cortical neurons and map their connectomes, revealing organizational principles of brain-wide networks at the single-cell level.

Integrated multimodal cell atlas of Alzheimer's disease

This study creates an integrated multimodal cell atlas of Alzheimer's disease by analyzing single nuclei transcriptomes, epigenomes, and spatial coordinates across AD stages.

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

The paper investigates target cell-specific synaptic dynamics between excitatory and inhibitory neurons in human neocortex, finding similarities to rodent studies.

Integrating EM and Patch-seq data: Synaptic connectivity and target specificity of predicted Sst transcriptomic types

The paper predicts MET-type identities from EM data and shows they have distinct connectivity patterns and synapse targets.

Regional and cell type-specific afferent and efferent projections of the mouse claustrum

This study maps the cell-type-specific afferent and efferent projections of the mouse claustrum using viral tracing and single-neuron reconstruction, revealing its widespread connections and regional specificity.

Multi-modal characterization and simulation of human epileptic circuitry

This study characterizes and simulates changes in human hippocampal granule cells during epilepsy progression, identifying ion channel modifications that increase excitability.

Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex

The paper presents a synaptic physiology dataset and analysis platform to study cortical microcircuit structure and synaptic properties in mouse and human neocortex, revealing layer-dependent connectivity and subclass-specific dynamics.

High-throughput analysis of dendritic and axonal arbors reveals transcriptomic correlates of neuroanatomy

The paper analyzes dendritic and axonal arbors of inhibitory neurons to identify transcriptomic correlates of neuroanatomy.

Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

Signature morpho-electric, transcriptomic, and dendritic properties of extratelencephalic-projecting human layer 5 neocortical pyramidal neurons

The paper identifies conserved and divergent morpho-electric and transcriptomic properties of human and rodent layer 5 extratelencephalic-projecting neurons using patch-seq in human brain slices.

Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization

The paper describes an optimized Patch-seq technique for high-quality electrophysiological, morphological, and transcriptomic characterization of neurons, along with software tools for data acquisition and analysis.

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

The paper characterizes transcriptomic and physiological properties of GABAergic cortical neurons in mice, identifying 20 interneuron met-types with consistent features across modalities.

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.

The organization of intracortical connections by layer and cell class in the mouse brain

The paper expands the Allen Mouse Brain Connectivity Atlas by analyzing intracortical connections at the layer and cell class level, revealing modular organization and distinct projection patterns.

Classification of electrophysiological and morphological types in mouse visual cortex

The paper classifies neurons in mouse visual cortex into 17 electrophysiological and 35 morphological types using unsupervised methods and links them to transcriptomic types.

Visual physiology of the Layer 4 cortical circuit in silico

The paper develops a biophysically detailed in silico model of layer 4 of the mouse primary visual cortex, showing how functional synaptic connectivity reproduces experimental observations of neuronal responses to visual stimuli.