Costas A. Anastassiou

Selective gating of neural modulation through frequency- and behavior-dependent modes during cortical electrical stimulation

The paper investigates how different stimulation frequencies and behavioral states influence neural responses during cortical electrical stimulation in mice.

Cell class-specific electric field entrainment of neural activity

The paper investigates how electric fields affect different cortical neuron classes, finding frequency-dependent entrainment and class-specific responses in rodent and human neurons.

Associations between in vitro, in vivo and in silico cell classes in mouse primary visual cortex

The paper links in vitro, in vivo, and in silico cell classes in mouse visual cortex using computational modeling and optotagging experiments to identify distinct clusters with specific properties.

Multi-modal characterization and simulation of human epileptic circuitry

This study characterizes and simulates changes in human hippocampal granule cells during epilepsy progression, identifying ion channel modifications that increase excitability.

Single-neuron models linking electrophysiology, morphology and transcriptomics across cortical cell types

The paper generates and evaluates over 130 million single-neuron models with active conductances to link electrophysiology, morphology, and transcriptomics across cortical cell types.

Chandelier cell anatomy and function reveal a variably distributed but common signal

The paper maps chandelier cell synapses onto pyramidal neurons and finds variability in synaptic input correlated with target neuron features, while showing functional correlation with arousal state.

Classification of electrophysiological and morphological types in mouse visual cortex

The paper classifies neurons in mouse visual cortex into 17 electrophysiological and 35 morphological types using unsupervised methods and links them to transcriptomic types.

h-channels contribute to divergent electrophysiological properties of supragranular pyramidal neurons in human versus mouse cerebral cortex

The paper shows that h-channels contribute to differences in electrophysiological properties between human and mouse supragranular pyramidal neurons.

Real-time spike sorting platform for high-density extracellular probes with ground-truth validation and drift correction

Covariance-based features plus unsupervised density-peak clustering sort spikes from up to 1000 channels in real time on one workstation, while tolerating noise and probe drift.