Author

Fadi Nikola

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:imaging· 2

Frequent Co-Authors

Naftali KaminskiiD· 5 shared Taylor Sterling AdamsiD· 5 shared A. JustetiD· 3 shared Xiting YaniD· 3 shared Edward P. ManningiD· 2 shared Farida AhangariiD· 2 shared Iván O. RosasiD· 2 shared Johad KhouryiD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCell Biology

Naftali KaminskiORCID

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Author profile →

5 papers

Recent·Most cited

Multi-omics reveals a monocyte-macrophage-fibroblast axis in post-COVID-19 fibroinflammatory lung remodelling

Puja Mehta, Connar M. Mawer, Gordon Beattie, David J. F. Smith, Fadi Nikola, Hugh Selway‐Clarke, A Y Zhao, Taylor Sterling Adams, Annabel Kunzemann-Martinez, Stefan Cristian Stanel, Kaylee B. Worlock, Masahiro Yoshida, Rachel Walters, Sian Goldsworthy, Imran Uddin, , Rachel Clare Chambers

This study identifies a monocyte-macrophage-fibroblast axis in post-COVID-19 lung fibrosis using multi-omic profiling and shows its potential as a therapeutic target.

bioRxiv · Sep 14, 2026 · PreprintSystems Biology

Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis

Neil J. McKenna, Scott A. Ochsner, Alan Waich, Juan Cala-García, Maria E. Ruiz Echartrea, Sandra L. Grimm, Fernando Poli, Rafael Cardenas Castillo, Juan D. Zuluaga, Sergio Poli, Taylor Sterling Adams, Ricardo Pineda, B.J. Moss, Tianshi David Wu, Charles G. Minard, , Iván O. Rosas

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

bioRxiv · Jun 16, 2025 · PreprintCell Biology

Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis

Taylor Sterling Adams, Jonas C. Schupp, Agshin Balayev, Johad Khoury, A. Justet, Fadi Nikola, Laurens De Sadeleer, Juan Cala-García, Marta Zapata‐Ortega, Panayiotis V. Benos, John E. McDonough, Farida Ahangari, Mélanie Königshoff, Jun Ding, Robert Homer, , Naftali Kaminski

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

bioRxiv · Jun 10, 2025 · PreprintCell Biology✦ In-depth digest

Hypoxia-Induced Cardiopulmonary Remodeling and Recovery: Critical Roles of the Proximal Pulmonary Artery, Macrophages, and Exercise

Abhay B. Ramachandra, Prapti Sharma, Ruben De Man, Fadi Nikola, Nicole M. Guerrera, Pramath Doddaballapur, Cristina Cavinato, Rira Choi, Micha Sam Brickman Raredon, Jason M. Szafron, Zhen W. Zhuang, Thomas Bärnthaler, A. Justet, Ngozi D. Akingbesote, Nebal S. Abu Hussein, , Edward P. Manning

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

bioRxiv · Feb 15, 2025 · PreprintPhysiology

The role of GPR87 in Pulmonary Fibrosis

Johad Khoury, Farida Ahangari, Taylor Sterling Adams, A. Justet, Edward P. Manning, John E. McDonough, Thomas Bärnthaler, Sabina Anderson, Fadi Nikola, Mary Lou Beermann, José L. Gómez, Naftali Kaminski

This study investigates GPR87's role in pulmonary fibrosis, finding it highly expressed in IPF lungs and protective against fibrosis when knocked down in multiple models.

bioRxiv · Oct 10, 2024 · PreprintCell Biology