OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies
Qinglong Wang, Yiqi Wang, Yong‐hui Jiang, Ryan Donahue, Gaby Cao, Weixuan Yan, Hong Guo, Zhenghui Li, Jenna Liang, Jin Hao, Yi Lu, Fengfeng Bei, Qianbin Wang, Feng Tian
This study shows that OPTN dysfunction leads to neuroinflammation and RGC death in glaucoma, independent of IOP, and identifies OPTN-NPY signaling as a potential therapeutic target.
Communications Biology · Oct 16, 2025Peer-reviewedNeuroscience