Changyang Linghu

Genetically encoded systems for cytosolic activity recording and molecular archiving across time

This paper introduces CyTRACE, a genetically encoded framework for recording cytosolic activity and archiving molecules over time in mammalian cells.

Simultaneous brain-wide single-cell recording resolves spatiotemporal memory architecture

The paper introduces GLOBE, a brain-wide single-cell recording technology, and demonstrates its use in capturing Fos transcriptional activity across a mouse brain over time.

Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes

This paper introduces CytoTape, a tool for continuous, multiplexed recording of gene regulation dynamics over weeks at single-cell resolution, and demonstrates its use in measuring transcription factor activities.

Pixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy

This paper introduces a high-speed camera with programmable pixel sampling that improves signal-to-noise ratio, enabling detection of weak neuronal activity.

Recording of cellular physiological histories along optically readable self-assembling protein chains

The paper introduces a method to record cellular physiological histories using self-assembling protein chains that can be optically read, demonstrating its use in neurons and mouse brain.

Precision calcium imaging of dense neural populations via a cell body-targeted calcium indicator

The paper develops cell body-targeted calcium indicators to improve signal fidelity in one-photon imaging of neural activity in live mice and zebrafish.