A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity
Liza Malong, Jessica Roskosch, Carolina Hager…·Filip Roudnicky
The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.