A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity
Liza Malong, Jessica Roskosch, Carolina Hager, Jean‐Philippe Fortin, Roland Schmucki, Marinella G. Callow, Christian Weile, Valentina Romeo, Christoph Patsch, Scott E. Martin, Mike Costa, Zora D. Modrusan, Roberto Villaseñor, Erich Koller, Benjamin Haley, , Filip Roudnicky
The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.
Nature Communications · Jun 30, 2025Peer-reviewedCell Biology