Kyriaki Galani

Length-dependent hypercontractility decoupled from cellular adaptations is the initial phenotype in MYBPC3-haploinsufficient iPSC-derived engineered cardiac tissues

This study identifies length-dependent hypercontractility as the initial phenotype of MYBPC3-haploinsufficiency in iPSC-derived cardiac tissues, decoupled from early transcriptional and metabolic changes.

Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome associated Alzheimer disease

The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.

Convergent Signals Encode Persistent Memory of Resilient States

The paper identifies convergent signals that encode epigenetic memory of adaptive states in NK cells under dietary restriction, showing how these signals reduce DNA damage and enhance metabolic plasticity.

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimers Disease with Psychosis

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

QClus: A droplet-filtering algorithm for enhanced snRNA-seq data quality in challenging samples

QClus improves snRNA-seq data quality by filtering droplets in challenging samples, achieving high quality across multiple datasets and metrics.

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

Cardiovascular disease causes proinflammatory microvascular changes in the human right atrium

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

Huntington's Disease Produces Multiplexed Transcriptional Vulnerabilities of StriatalD1-D2 and Striosome-Matrix Neurons

The paper examines transcriptional changes in striatal neurons in Huntington's disease, finding that striosomal SPNs are most depleted and compartmental markers are dysregulated in both mouse models and human HD.

Single-cell multi-region dissection of brain vasculature in Alzheimer's Disease

The paper identifies cell-type-specific molecular changes in cerebrovascular cells across brain regions in Alzheimer's Disease, linking them to genetic variants and potential therapeutic targets.

Metabolic resilience is encoded in genome plasticity

The paper investigates how genome plasticity and transcriptional organization enable metabolic resilience to nutrient limitation and fasting endurance.

Single-cell dissection of the human cerebrovasculature in health and disease

This study characterizes human cerebrovascular cells in health and disease, identifying cell type-specific markers and revealing immune activation and BBB integrity loss in Huntington's disease.