Author
Fred and Pamela Buffett Cancer CenterORCID 0000-0003-2583-8849Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Qiang Liu, Joshua B. Wallach, Yahani P. Jayasinghe…·Courtney C. Aldrich
The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.
Rakesh Roy, Yahani P. Jayasinghe, Sasmita Panda…·James P. O’Gara
This study identifies a S180F substitution in D-alanine aminotransferase (Dat) in Staphylococcus aureus that confers resistance to β-chloro-D-alanine by altering PLP co-factor binding and promoting antibiotic inactivation.
Sasmita Panda, Yahani P. Jayasinghe, Dhananjay D. Shinde…·Vinai Chittezham Thomas
This study shows that Staphylococcus aureus counters acetate-mediated inhibition of peptidoglycan cross-linking by maintaining high intracellular D-Ala levels through alanine racemase and limiting D-Ala flux via D-alanine aminotransferase.