William K. J. Benman

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

The paper shows that proteins can dynamically encode environmental information through domain interactions, with pulsatory responses shaped by light, temperature, and evolution.

This paper introduces a temperature-inducible protein module called Melt that allows reversible control of mammalian cell processes through temperature changes, demonstrating its utility in cell death control in a mouse cancer model.

The paper introduces thermoPlate, a device for dynamic temperature control in cell culture, and uses it to study temperature-dependent cellular responses like phase separation and stress granule dynamics.

The paper introduces an open-source device for high-throughput optogenetic experiments in microwell plates, enabling automated stimulation, spectroscopy, and feedback control in E. coli.

This paper introduces CREATE, a genetic circuit platform that enables complex signal processing in mammalian cells through programmable transcription factors and site-specific recombination.

The paper introduces a library of inducible split recombinases for precise and multiplexed gene expression control in mammalian cells and mice.