Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer
Anaïs Darracq, Nicolas Sgarioto, Marielle Huot, Gabrielle McInnes, Antoine Méant, Alexandra Langford‐Avelar, Oscar David Villarreal, François Marois, Maxime Caron, Pascal St-Onge, Séverine Leclerc, Gaël Cagnone, Grégor Andelfinger, Stéphane Richard, Daniel Sinnett, , Noël J.‐M. Raynal
This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.
bioRxiv · Jan 23, 2025 · PreprintCancer Biology