Jazmina L. Gonzalez Cruz

This study shows that CHK1i+LDHU reprograms tumour-associated macrophages to an inflammatory state while preserving immunosuppressive features, enhancing CD8 T cell activation and therapeutic efficacy.

The paper identifies 354,937 novel lncRNAs across 13 cancer types using single-cell and spatial transcriptomics, revealing their cell-type specificity, spatial distribution, and potential functional roles.

This study evaluates CHK1i+LDHU therapy in HGSOC, showing it kills cancer cells and reprograms the tumor microenvironment to enhance anti-tumor immune responses.

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.