Brian G. Gabrielli

This study shows that CHK1i+LDHU reprograms tumour-associated macrophages to an inflammatory state while preserving immunosuppressive features, enhancing CD8 T cell activation and therapeutic efficacy.

This study evaluates CHK1i+LDHU therapy in HGSOC, showing it kills cancer cells and reprograms the tumor microenvironment to enhance anti-tumor immune responses.

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.