Martina A. Proctor

Reprogramming tumour-associated macrophages from immune suppressive to inflammatory state by Checkpoint kinase 1 inhibitor combination treatment

This study shows that CHK1i+LDHU reprograms tumour-associated macrophages to an inflammatory state while preserving immunosuppressive features, enhancing CD8 T cell activation and therapeutic efficacy.

Using targeted therapy to promote a pro-inflammatory tumour microenvironment and anti-tumour immune response in high grade serous ovarian cancer

This study evaluates CHK1i+LDHU therapy in HGSOC, showing it kills cancer cells and reprograms the tumor microenvironment to enhance anti-tumor immune responses.

Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.