Zachary T. Baumer

The paper designs dynamic biosensors for detecting nitazenes and their metabolites using computational methods, achieving low nanomolar detection limits and limited cross-reactivity.

This paper computationally redesigns T7 RNA polymerase to increase its thermal stability, achieving a T50 of 54.9°C with 59% wild-type activity at 37°C.

The paper designs and engineers minimal protein-based molecular inverters and switches that respond to ligands, demonstrating tunable and modular control of post-translational signaling.

This paper shows that engineered T7 RNA polymerases can be controlled by indoles, enabling chemically inducible gene expression in synthetic biology applications.

The paper measures EC50 values for T7 RNA polymerase constructs and identifies the C-terminal T7 as a competitive inhibitor with a lower inhibition constant than the EC50 of full-length T7 RNAP.

The paper introduces MAGMA-seq, a technology for quantitative analysis of antibody sequence-function relationships, demonstrating its application in mapping antibody development pathways and identifying binding determinants.

The paper identifies 5 stabilizing mutations for PYR1 variants using GMMA that increase thermal stability without affecting functionality across different ligand-binding capabilities.