Author

Alex C.H. Liu

University Health NetworkORCID 0000-0003-2704-329XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron David SchimmeriD· 1 shared Abdula MaheriD· 1 shared Alexander F. A. KeszeiiD· 1 shared Andrea ArrudaiD· 1 shared Brian RaughtiD· 1 shared Christopher B. MarshalliD· 1 shared David L. DaiiD· 1 shared Dhanoop Manikoth AyyathaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aaron David SchimmerORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 12, 2026

CD59 organizes the plasma membrane to sustain oncogenic Ras-MAPK signaling and is a targetable vulnerability in acute myeloid leukemia

Abdula Maher, Dhanoop Manikoth Ayyathan, Séverine Cathelin…·Steven M. Chan

This study identifies CD59 as a critical regulator of Ras-MAPK signaling in AML, showing its depletion impairs leukemic growth and identifies rILYd4 as a potential therapeutic target.

DOI 10.64898/2026.08.11.744285

humanbulk RNA-seq

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BiochemistryJournal of Molecular BiologyPeer-reviewedMar 28, 2025

Cryo-EM of AKAP350 reveals fibrillar clusters and a potential association with DNA

David L. Dai, Alexander F. A. Keszei, Elena A. KOLOBOVA…·Mohammad T. Mazhab‐Jafari

This study uses cryo-EM to show AKAP350 forms fibrillar clusters and interacts with DNA and DNA-binding proteins like NFIB and NCL.

1 citation

humancryo-EM

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