Author

Steven M. Chan

University Health NetworkORCID 0000-0002-4354-0731Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

Andrea ArrudaiD· 3 shared Mark David MindeniD· 3 shared Angelica VaresiiD· 2 shared John Edgar DickiD· 2 shared Mohsen HosseiniiD· 2 shared Sagi AbelsoniD· 2 shared Stephanie Zhi-Juan XieiD· 2 shared Yitong YangiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

Andrea ArrudaORCID

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5 papers

Recent·Most cited

Cell-state-dependent responses to PLK1 inhibition reveal a non-canonical microtubule-endolysosomal vulnerability in quiescent leukemia stem cells

Qiang Liu, Milena Gojsevic, Angelica Varesi, Amit Subedi, Changjjiang Xu, Faith Au Yeung, Bailey Dinel, Nathan Mbong, Liqing Jin, Amanda Mitchell, Cassie Lim, Héléna Boutzen, Andrea Arruda, Mark D Minden, Eric R. Lechman, , Jean CY Wang

This study shows that PLK1 inhibition eradicates quiescent leukemia stem cells through a non-canonical mechanism involving microtubule and endolysosomal disruption, distinct from its canonical mitotic function.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

CD59 organizes the plasma membrane to sustain oncogenic Ras-MAPK signaling and is a targetable vulnerability in acute myeloid leukemia

Abdula Maher, Dhanoop Manikoth Ayyathan, Séverine Cathelin, Paige Roehrig, Stephanie Z. Liu, Yitong Yang, Alex C.H. Liu, Mohsen Hosseini, Elise Quadri, Tiffany Villeneuve, Simi Kaur, Vivian Wang, Erwin M. Schoof, Andrea Arruda, Mark David Minden, , Steven M. Chan

This study identifies CD59 as a critical regulator of Ras-MAPK signaling in AML, showing its depletion impairs leukemic growth and identifies rILYd4 as a potential therapeutic target.

bioRxiv · Aug 12, 2026 · PreprintCancer Biology

Aberrant oxidative metabolism selects for TET2-deficient hematopoietic stem and progenitor cells

Katia E. Niño, Vera Ademà, Alyx E. Gray, Courtney M Cowan, Wolfgang E. Schleicher, Mohsen Hosseini, Sierra N. Bennett, Sweta B. Patel, Steven Moreira, Etienne P. Danis, Feyiang Ma, Hsin-Ying Lin, Tracy N. Young, Colin A. Anderson, Devyani Sharma, , Eric Martin Pietras

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

bioRxiv · Mar 2, 2026 · PreprintCancer Biology

Blood-based Epigenetic Instability Linked to Human Aging and Disease

Salman Basrai, Ido Nofech-Mozes, Rajesh Detroja, Fernando Luís Scolari, Mehran Bakhtiari, Andrea Arruda, Tracy Murphy, Scott Victor Bratman, Steven M. Chan, Mark David Minden, J H Ahn, Dennis D. H. Kim, Robert Kridel, Filio Billia, Sagi Abelson

This study identifies DNA methylation instability in blood cells linked to aging and disease, showing age-related instability and associations with cardiovascular disease and cancer.

Nature Communications · Feb 14, 2026Peer-reviewedGenetics

Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

Vincent Rondeau, Suraj Bansal, Marco M. Buttigieg, Andy G.X. Zeng, Darryl Y. Chan, Michelle Chan‐Seng‐Yue, Jin Liqing, Jessica L. McLeod, Meghan Kates, Elisa Donato, Patrick Stelmach, Caitlyn Vlasschaert, Yitong Yang, Aarushi Gupta, Sofia Genta, , Robert J. Vanner

This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.

Cancer Research · Nov 11, 2025Peer-reviewedCancer Biology