CD59 organizes the plasma membrane to sustain oncogenic Ras-MAPK signaling and is a targetable vulnerability in acute myeloid leukemia
Abdula Maher, Dhanoop Manikoth Ayyathan, Séverine Cathelin, Paige Roehrig, Stephanie Z. Liu, Yitong Yang, Alex C.H. Liu, Mohsen Hosseini, Elise Quadri, Tiffany Villeneuve, Simi Kaur, Vivian Wang, Erwin M. Schoof, Andrea Arruda, Mark David Minden, , Steven M. Chan
This study identifies CD59 as a critical regulator of Ras-MAPK signaling in AML, showing its depletion impairs leukemic growth and identifies rILYd4 as a potential therapeutic target.
bioRxiv · Aug 12, 2026 · PreprintCancer Biology