Hamed Shateri Najafabadi

The paper shows that PKM inhibits translation of 7% of the transcriptome under high glucose and pyruvate conditions by stalling ribosome elongation, linking glycolysis to protein synthesis and cell cycle regulation.

The paper identifies TARBP2 as a nuclear RNA-binding protein that regulates transcript stability through m6A methylation, splicing inhibition, and exosome-mediated degradation, with implications for lung cancer progression.