Timothy L. Karr

Evolution and adaptations of the seminal proteome in an insect with traumatic insemination

The paper characterizes the sperm and seminal fluid proteome of bedbugs, revealing evolutionary adaptations linked to traumatic insemination and identifying expanded S-Laps with potential catalytic activity.

Towards a Kingdom of Reproductive Life - the Core Sperm Proteome

This study integrates proteomic data from 12 vertebrate species to identify a core sperm proteome, revealing conserved molecular pathways and validating novel proteins critical for fertility.

A public resource of single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease

The paper provides a public resource of single nucleus RNA sequencing data and multiscale networks from Alzheimer's disease and non-disease individuals, linking genetic variants to molecular features and revealing novel disease biology.

Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimers disease hallmarks

This study shows that dietary choline deficiency in AD model mice leads to organ pathology and worsens Alzheimer's disease hallmarks.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

Sexual selection rewires reproductive protein networks

This study shows that postcopulatory sexual selection drives rapid evolution of the male accessory gland proteome and rewires protein networks in Drosophila pseudoobscura.