Author
University of Wisconsin–MadisonORCID 0000-0003-2948-8831Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Kaivalya Molugu, Ruba Halaoui, Mohammed Zeaiter…·Chong T. Luo
This paper introduces a novel genome engineering method for iPSCs that enables efficient multiplex gene editing and clone selection, improving the precision and speed of iPSC-based therapies.
Angela X. Nan, Michael Chickering, Christopher L. Bartolome…·Jenny Xie
This paper introduces L-PGI, a ligase-mediated gene editing system that enables efficient and precise genomic integration in both dividing and nondividing cells, overcoming limitations of reverse transcriptase-based methods.
Dane Z. Hazelbaker, Japan B. Mehta, Connor McGinnis…·Daniel J. O’Connell
The paper develops and validates methods to detect off-target recombination by Large Serine Integrases, finding higher sensitivity than whole genome sequencing.
Meha Kabra, Mariya Moosajee, Gregory A. Newby…·Bikash Ranjan Pattnaik
The paper evaluates CRISPR base editors for correcting a KCNJ13 mutation causing LCA16, finding high on-target efficiency but negligible channel function due to bystander edits and mRNA structural issues.