Author

Chiara Mastroleo

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

Andrea VenturaiD· 3 shared Gaspare La RoccaiD· 3 shared Kevin M. HaigisiD· 3 shared Minsi ZhangiD· 3 shared Xiaoyi LiiD· 3 shared Doron BeteliD· 2 shared Joana Alves VidigaliD· 2 shared João A. PauloiD· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Andrea VenturaORCID

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Author profile →

3 papers

Recent·Most cited

miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

Minsi Zhang, Ziqi Jiao, Ylenia Cendon Florez, Ivana Lessel, Xiaoyi Li, Melissa A. Yao, Moritz Weigl, Mateusz M. Ozimek, Turgut Dogruluk, Kevin Chen, Keith Conrad Fernandez, Vinagolu K. Rajasekhar, Olesja Popow, João A. Paulo, Davide Pradella, , Gaspare La Rocca

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

bioRxiv · Dec 15, 2025 · PreprintCancer Biology

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

Gaspare La Rocca, Bryan King, Bing Shui, Xiaoyi Li, Minsi Zhang, Kemal Marc Akat, Paul Ogrodowski, Chiara Mastroleo, Kevin Chen, Vincenzo Cavalieri, Yilun Ma, Viviana Anelli, Doron Betel, Joana Alves Vidigal, Thomas Tuschl, , Andrea Ventura

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

eLife · Aug 31, 2021Peer-reviewedMolecular Biology

High-resolution in vivo identification of miRNA targets by Halo-Enhanced Ago2 Pulldown

Xiaoyi Li, Yuri Pritykin, Carla P. Concepcion, Yuheng Lu, Gaspare La Rocca, Minsi Zhang, Peter J. Cook, Yu Wah Au, Olesja Popow, João A. Paulo, Hannah G. Otis, Chiara Mastroleo, Paul Ogrodowski, Ryan P. Schreiner, Kevin M. Haigis, , Andrea Ventura

This paper introduces a method to identify miRNA targets in vivo using Halo-Enhanced Ago2 Pulldown and demonstrates its application in mouse models.

bioRxiv · Oct 28, 2019 · PreprintMolecular Biology