Author

Ali Khoshnan

California Institute of TechnologyORCID 0000-0002-0070-9808Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Anjalika ChongthamiD· 2 shared Anoop RawatiD· 2 shared Jung Hyun Yoo· 2 shared Ralf LangeniD· 2 shared Ainul HudaiD· 1 shared Åsa PeterséniD· 1 shared Baiyi QuaniD· 1 shared Joan MarshiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Anjalika ChongthamORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ENAH Binding to the Huntingtin Proline-Rich Domain Modulates HTT1a Assembly

Jobin Varkey, Anoop Rawat, Priyatama Pandey, Baiyi Quan, Tsui‐Fen Chou, Ralf Langen, Ali Khoshnan

This study identifies ENAH as an interactor of the HTT1a PRD and shows that EVH1 domain binding modulates HTT1a aggregation and fibril remodeling.

bioRxiv · Aug 2, 2026 · PreprintNeuroscience

Gut bacteria regulate the pathogenesis of Huntington's disease in Drosophila model

Anjalika Chongtham, Jung Hyun Yoo, Theodore M. Chin, Ngozi D. Akingbesote, Ainul Huda, Joan Marsh, Ali Khoshnan

This study shows that gut bacteria influence Huntington's disease progression in Drosophila models, with antibiotics and compounds like crocin reducing disease symptoms while E. coli worsens them.

Frontiers in Neuroscience · Jun 2, 2022Peer-reviewedNeuroscience

IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model

Rana Soylu-Kucharz, Ali Khoshnan, Åsa Petersén

This study shows that hypothalamic expression of mutant HTT causes sex-specific metabolic imbalance, and IKKβ inhibition reduces obesity in female HD mice.

iScience · Jan 19, 2022Peer-reviewedNeuroscience

Sonicated fibrils of huntingtin exon-1 preferentially seed neurons and produce toxic assemblies

Anjalika Chongtham, Jose Mario Isas, NITIN KUMAR PANDEY, Anoop Rawat, Jung Hyun Yoo, Tara L Mastro, Mary B. Kennedy, Ralf Langen, Ali Khoshnan

This study shows sonicated HTTex1 fibrils selectively seed neurons, leading to toxic assemblies and neuronal damage.

Neurobiology of Disease · Sep 24, 2021Peer-reviewedNeuroscience