Xuan Zhou

This study shows that modulating the MMEJ pathway components RPA and POLQ can reduce large deletions and enhance HDR after CRISPR-Cas9 editing.

This paper introduces iMiGseq, a method for ultra-sensitive mtDNA sequencing in oocytes, revealing hidden heterogeneity and deleterious variants in human and mouse samples.

The paper develops a method to quantify rare genetic variants in human cells using long-read sequencing and shows CRISPR-Cas9 induces nonrandom large deletions and insertions.