Author

Yanjiao Shao

Altos LabsORCID 0000-0001-7204-3534Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Baolei YuaniD· 2 shared Chongwei BiiD· 2 shared Juan Carlos Izpisúa BelmonteiD· 2 shared Mo LiiD· 2 shared Xuan ZhouiD· 2 shared Yanyi HuangiD· 2 shared Fernanda Vargas Romero· 1 shared Gang YiiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMolecular Biology

Baolei YuanORCID

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2 papers

Recent·Most cited

Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks

Baolei Yuan, Chongwei Bi, Yeteng Tian, Jincheng Wang, Yiqing Jin, Khaled N. Alsayegh, Muhammad Tehseen, Gang Yi, Xuan Zhou, Yanjiao Shao, Fernanda Vargas Romero, Wolfgang Fischle, Juan Carlos Izpisúa Belmonte, Samir M. Hamdan, Yanyi Huang, Mo Li

This study shows that modulating the MMEJ pathway components RPA and POLQ can reduce large deletions and enhance HDR after CRISPR-Cas9 editing.

BMC Biology · Apr 29, 2024Peer-reviewedMolecular Biology

Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes

Chongwei Bi, Lin Wang, Yong Fan, Gerardo Ramos‐Mandujano, Baolei Yuan, Xuan Zhou, Jincheng Wang, Yanjiao Shao, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisúa Belmonte, Mo Li

This paper introduces iMiGseq, a method for ultra-sensitive mtDNA sequencing in oocytes, revealing hidden heterogeneity and deleterious variants in human and mouse samples.

bioRxiv · Dec 28, 2020 · PreprintGenomics