Maarten Merkx

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

This paper introduces a method to create homogeneous antibody-DNA conjugates using unmodified oligonucleotides and photo-crosslinkable protein G-HUH endonuclease fusion proteins, achieving 1:1 stoichiometry.

The paper introduces a computational package for visualizing, describing, and comparing nanoparticle datasets from super-resolution microscopy to analyze material properties and heterogeneity.

The paper designs protein competitors for small molecule detection using deep learning, demonstrating effective binders for digoxin detection.

This paper introduces GLOVID, a biosensor platform that detects intact respiratory viruses by reconstituting split luciferase, achieving ultrasensitive detection of influenza A and RSV.

This paper develops a scalable synthetic communication platform for mammalian cells using orthogonal receptors and coiled-coil peptides to enable logic gate computations in cell consortia.

This paper introduces a living material platform that traps engineered E. coli in hydrogels using adhesin-mediated anchoring, reducing bacterial leakage and enabling controlled release of antimicrobial proteins.