Sarah J. Shemtov

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

Down syndrome with Alzheimers disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.