Kang I. Ko

This study shows that matrix stiffness influences epigenomic changes in gingival fibroblasts, with stiff matrices promoting CpG methylation and reduced inflammation, while soft matrices lead to hypomethylation and increased inflammatory signaling.

This paper presents a single-cell and spatial proteotranscriptomic atlas of human oral tissues, identifying fibroblasts as key immunoregulatory hubs and revealing changes in disease states.

This study shows that matrix stiffness influences fibroblast-driven immune responses in gingival tissues, with stiff matrices reducing inflammation through non-canonical NFκB and epigenetic pathways.

The paper identifies CD38⁺ endothelial remodeling as a spatially distinct vasculopathy feature in rapidly advancing oral inflammation using scRNA-seq and spatial proteomics.

This study reveals how persistent intracellular bacterial macromolecules in mucosal epithelial cells drive inflammatory signaling, offering new insights into microbial-host interactions and their potential impact on inflammatory disease treatment and drug efficacy.