Author

Zarife Sahenk

Nationwide Children's HospitalORCID 0000-0003-2974-3943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Afrooz RashnonejadiD· 1 shared Allison M. BradburyiD· 1 shared Beibei Chen· 1 shared Ben Kelly· 1 shared Burçak ÖzeşiD· 1 shared Colin T. MaguireiD· 1 shared Devi Jaganathan· 1 shared Ebru Erzurumluoğlu GökalpiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Afrooz RashnonejadORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 29, 2025

REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers

Yasemin Sezgin, Genesis Snyder, Noushin Saljoughian…·Meisam Naeimi Kararoudi

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

DOI 10.1101/2025.05.29.641201

humanmouse

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Molecular BiologyeLifePeer-reviewedFeb 8, 2019

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Florian B. Kopp, Mehmet Emir YALVAÇ, Beibei Chen…·Joshua T. Mendell

This study shows that loss of the lncRNA Norad leads to PUMILIO hyperactivity, causing genomic instability and mitochondrial dysfunction, resulting in premature aging in mice.

98 citationstop 4%

mouseDNA methylation

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