Author

Jyrki Heino

University of TurkuORCID 0000-0003-2978-805XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Pekka RappuiD· 4 shared Antti M. SaloiD· 2 shared Emma KarjalaineniD· 2 shared Ilkka MiinalaineniD· 2 shared Johanna MyllyharjuiD· 2 shared Valerio IzziiD· 2 shared Cecilia SahlgreniD· 1 shared Fuping ZhangiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCancer Biology

Pekka RappuORCID

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4 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedMar 18, 2026

Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer

Marjaana Parikainen, Ujjwal Suwal, Pekka Rappu…·Cecilia Sahlgren

This study shows Jagged1 promotes ECM remodeling in TNBC by enhancing fibroblast activation and TGFβ signaling, suggesting it as a therapeutic target.

7 citationstop 1%

humanproteomics

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BiochemistrybioRxivPreprintDec 23, 2025

P4HA3 is abundantly expressed during early embryonic development, but does not catalyze the formation of 4-hydroxyproline in type I collagen

Emma Karjalainen, Pekka Rappu, Valerio Izzi…·Antti M. Salo

DOI 10.64898/2025.12.22.695897

mouseproteomics

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Molecular BiologybioRxivPreprintJun 28, 2023

Collagen prolyl 4-hydroxylases have sequence specificity towards different X-Pro-Gly triplets

Antti M. Salo, Pekka Rappu, M. Kristian Koski…·Johanna Myllyharju

This study identifies sequence specificity of collagen prolyl 4-hydroxylase isoenzymes for different X-Pro-Gly triplets and their impact on collagen stability and assembly.

2 citations

statistical model

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Developmental BiologybioRxivPreprintJul 5, 2021

Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality

Salli Talvi, Johanna Jokinen, Kalle H. Sipilä…·Jyrki Heino

The paper shows that Embigin deficiency causes delayed embryonic lung development and high neonatal mortality in mice.

1 citation

mousebulk RNA-seq

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