Yuuta Imoto

The paper shows microglia extract proteolytic organelles from neurons via a process called skoupocytosis, which bypasses retrograde transport and aids neuronal homeostasis.

The paper uses zap-and-freeze electron microscopy to study synaptic vesicle dynamics in mouse and human brain slices, revealing conserved endocytic mechanisms.

The paper shows that Dynamin 1xA forms molecular condensates with Syndapin 1 at endocytic sites, enabling ultrafast endocytosis by bypassing the recruitment step.

The paper shows that Dynamin 1xA and Syndapin 1 form liquid-like condensates at synapses, which facilitate ultrafast endocytosis by enabling molecular crowding and intermolecular interactions.

The paper identifies a novel activity-dependent mechanism involving Hrs and KIF13A for axonal transport of ESCRT machinery to facilitate synaptic vesicle protein degradation.