Raphaël Chèvre

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

This study shows NF-Y promotes myeloid cell survival and protects against inflammatory vascular disease by regulating transcriptional states in atherosclerosis.

The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

Divergent granulopoiesis at extramedullary sites safeguards host defense

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.

β-Glucan Reprograms Neutrophils to Induce Disease Tolerance Against Influenza A Virus

This study shows β-glucan reprograms neutrophils to induce disease tolerance against Influenza A virus by promoting a unique subset of neutrophils that limit tissue damage and enhance survival.