Divergent granulopoiesis at extramedullary sites safeguards host defense
Carlos Silvestre-Roig, Raphaël Chèvre, Alexander Bender, Lina-Marie Vöcking, Ali Hageb, Mathis Richter, Merieme Farjia, Quinte Braster, Mauricio Guzman, Jordi Sintes, Samriti Sharma, Patricia Lemnitzer, David Ahern, Collins Osei-Sarpong, Daniel Robert Engel, , Oliver Soehnlein
This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.
bioRxiv · Feb 25, 2025 · PreprintImmunology