Ahmad R. Hariri

The paper introduces DunedinPACNI, a brain MRI-based aging measure that predicts dementia conversion, morbidity, and mortality.

This paper introduces a stacking machine learning approach to improve predictability, test-retest reliability, and generalisability of brain-wide associations for cognitive abilities using multimodal MRI data.

The paper examines how functional topography of neocortical networks in midlife relates to covariation in motor and cognitive abilities, finding that motor ability reflects functional topography differences while hearing does not.

The paper examines the association between retinal neuronal layer thickness and brain structural integrity in midlife, finding thinner retinal layers correlate with reduced brain structural measures.

The paper compares meta-analysis maps (MAMs) of emotion categories with individual contrast maps (ICMs) from task fMRI data to identify affective processes related to threat-related facial expressions.

This study identifies brain connectivity patterns associated with trait anger using a large sample and connectome-wide analysis, finding hyperconnectivity in action-related regions.

The paper examines associations between childhood family emotional health, brain grey matter volume, and DNA methylation in saliva, finding mediation effects and enriched biological pathways.

The paper identifies a common pattern of reduced neocortical thickness across multiple psychiatric disorder categories and the general psychopathology factor.

The paper tests associations between Big Five personality traits and brain structure variability in 1,107 students, finding only a weak and inconsistent link between conscientiousness and superior temporal gyrus surface area.

Task-fMRI regional activation has poor test-retest reliability: meta-analytic mean intraclass correlation .397 across 77 un-thresholded substudies, and .067 to .485 for 11 tasks in HCP and Dunedin retest samples.

This study shows that older brain-age in midlife is linked to accelerated biological aging and cognitive decline, supporting brain-age as a biomarker while highlighting its potential to reflect lifelong CNS variation.

The paper replicates structural brain alterations linked to the p factor in a longitudinal cohort, finding support for cerebello-thalamo-cortical circuit and visual association cortex associations but not cerebellar morphology.

This study finds that higher maternal overprotection in childhood is linked to increased amygdala reactivity to explicit threat signals and reduced structural integrity of the uncinate fasciculus in young adulthood.

The paper identifies smaller brain volumes in the right dorsolateral prefrontal cortex and insula as predispositional risk factors for alcohol use, supported by genetic and longitudinal evidence.

The paper finds that a BMI polygenic score is associated with higher depressive symptoms in adulthood through increased early life stress.

The paper investigates whether genetic risk for rheumatoid arthritis is associated with brain morphology changes in healthy young adults before disease onset.

The paper associates a GWAS-derived polygenic score for IL-1β with hippocampal volume in two independent samples, showing a positive correlation.

The paper examines how white matter microstructural integrity moderates the link between childhood adversity and adult trait anger using diffusion MRI data.

This paper introduces General Functional Connectivity (GFC) to improve reliability and heritability of intrinsic connectivity estimates by combining resting-state and task fMRI data.

The paper examines how structural features of the corticolimbic circuit moderate the link between childhood adversity and trait anxiety in young adults.

This study finds that white matter hyperintensities (WMHs) are common in midlife and are associated with lower IQ and greater cognitive decline from childhood to midlife.

The paper finds that a polygenic score for educational attainment is associated with larger brain size and better cognitive test performance, suggesting a genetic link between brain size and intelligence.

The paper examines how subtle variations in caregiving, specifically familial affective responsiveness, influence amygdala reactivity to interpersonal threat in adolescents, revealing paradoxical associations with stress levels.

The paper identifies two trajectories of alcohol use initiation in adolescents and links early initiation to increased risk of AUD, stress, and amygdala reactivity.

The paper identifies a functional signature of transdiagnostic mental illness risk through hyper-connectivity between visual association cortex and frontoparietal and default mode networks.