Richie Poulton

Shared genetic architecture of brain age gap across 30 cohorts worldwide

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator

This study compares feature selection methods and machine learning algorithms to develop a DNA methylation-based telomere length estimator, finding that principal component analysis followed by elastic net regression performs best.

Functional Topography of the Neocortex Predicts Covariation in Complex Cognitive and Basic Motor Abilities

The paper examines how functional topography of neocortical networks in midlife relates to covariation in motor and cognitive abilities, finding that motor ability reflects functional topography differences while hearing does not.

Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain?

The paper examines the association between retinal neuronal layer thickness and brain structural integrity in midlife, finding thinner retinal layers correlate with reduced brain structural measures.

Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Resource Profile and User Guide of the Polygenic Index Repository

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

Investigating the Genetic Architecture of Non-Cognitive Skills Using GWAS-by-Subtraction

This study identifies 157 genome-wide significant loci associated with non-cognitive contributions to educational attainment, explaining 57% of genetic variance.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology

The paper identifies a common pattern of reduced neocortical thickness across multiple psychiatric disorder categories and the general psychopathology factor.

Quantification of the pace of biological aging in humans through a blood test: The DunedinPoAm DNA methylation algorithm

The paper develops a DNA methylation-based blood test, DunedinPoAm, to quantify individual differences in the pace of biological aging and validates its association with aging-related outcomes across multiple studies.

What is the test-retest reliability of common task-fMRI measures? Newempirical evidence and a meta-analysis

Task-fMRI regional activation has poor test-retest reliability: meta-analytic mean intraclass correlation .397 across 77 un-thresholded substudies, and .067 to .485 for 11 tasks in HCP and Dunedin retest samples.

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth-cohort

This study shows that older brain-age in midlife is linked to accelerated biological aging and cognitive decline, supporting brain-age as a biomarker while highlighting its potential to reflect lifelong CNS variation.

Replicability of Structural Brain Alterations Associated with General Psychopathology: Evidence from a Population-Representative Birth Cohort

The paper replicates structural brain alterations linked to the p factor in a longitudinal cohort, finding support for cerebello-thalamo-cortical circuit and visual association cortex associations but not cerebellar morphology.

General Functional Connectivity: shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks

This paper introduces General Functional Connectivity (GFC) to improve reliability and heritability of intrinsic connectivity estimates by combining resting-state and task fMRI data.

White matter hyperintensities are common in midlife and already associated with cognitive decline

This study finds that white matter hyperintensities (WMHs) are common in midlife and are associated with lower IQ and greater cognitive decline from childhood to midlife.

A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains

The paper finds that a polygenic score for educational attainment is associated with larger brain size and better cognitive test performance, suggesting a genetic link between brain size and intelligence.

Telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing?

This study evaluates seven biological aging measures in middle-aged humans, finding low agreement between them and modest associations with aging-related outcomes.