Brendan B. Larsen

This study measures the functional and antigenic effects of ~8,500 F protein mutations in Nipah virus using pseudoviruses, revealing constraints on its structure and neutralization by antibodies.

This paper identifies spike mutations in recent SARS-CoV-2 variants that reduce neutralization by human antibodies and clinically relevant monoclonal antibodies, highlighting key sites and mechanisms affecting antigenicity and function.

This study identifies amino-acid mutations in CHIKV envelope proteins that affect entry in human and mosquito cells, revealing species-specific determinants of viral tropism.

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.

January 2020 cases in Germany and Washington State were contained, while separate later introductions from China seeded the first sustained SARS-CoV-2 transmission networks in Italy and Washington State.