William W. Hannon

DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS

This paper describes the discovery of a potent monoclonal antibody, 4F11, that neutralizes HMPV with high efficacy and low resistance potential.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins

This study identifies amino-acid mutations in CHIKV envelope proteins that affect entry in human and mosquito cells, revealing species-specific determinants of viral tropism.

Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

dms-viz: Structure-informed visualizations for deep mutational scanning and other mutation-based datasets

dms-viz provides a web-based tool for visualizing mutation-based data in the context of 3D protein structures, improving the interpretation of mutation effects on protein function.

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains

This study develops a high-throughput sequencing-based neutralization assay to measure antibody titers against multiple influenza strains and finds that vaccination effects vary by individual and prior vaccination history.

Patterns of Structural Variation Define Prostate Cancer Across Disease States

This study identifies distinct structural variation patterns in prostate cancer across disease states, defining clinically actionable subgroups based on whole genome profiling.