Author

Karin Schlegelmilch

The Francis Crick InstituteORCID 0000-0003-3173-0914Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

Erik A. SahaiiD· 2 shared Sasha Bailey· 2 shared Steven HooperiD· 2 shared A. J. Narvaez· 1 shared A. M. I. Le MaroisiD· 1 shared Alexandrine CarminatiiD· 1 shared Amy L. BowesiD· 1 shared Benjamin ShumiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Erik A. SahaiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 23, 2025

Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma

Karin Schlegelmilch, Viola Hollek, Steven Hooper…·Erik A. Sahai

This study shows that cooperative and antagonistic interactions between sub-clones in melanoma allow multiple resistance mechanisms to coexist, and identifies GSK-J4 as a potential therapeutic target.

DOI 10.1101/2025.10.23.684170

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 14, 2024

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

A. M. I. Le Marois, Sasha Bailey, Steven Hooper…·Erik A. Sahai

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

3 citations

humanimaging

𝕏 PostBluesky