Jesse B. Hopkins

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

The paper uses TR-SAXS to study early G-quadruplex folding, revealing a rapid collapse followed by slower conformational changes.

The paper identifies a coiled-coil linker mechanism in RsbU that activates the General Stress Response in bacteria by transducing signals from sensor domains.

This paper uses SAXS and SANS to analyze conformational changes in RNA:RNA complexes, validating and improving AlphaFold 3 predictions through isotope labeling and contrast matching.

The paper investigates the structural context of homomeric interactions in the Ig domain of MPZ and their relation to CMT disease phenotypes using NMR and SAXS analysis.

This study presents the crystal structures of Sas6 and RbCBM74 bound to maltodecaose, showing their binding specificity for single and double helical α-glucan structures in starch.