Steven M. Holland

This study shows that GIMAP6 loss leads to inflammatory vasculopathy and atherosclerosis, causing heart failure and early death, and identifies GIMAP6 as a protective factor against cardiovascular disease.

This study identifies altered purinergic signaling and CD8+ T cell dysregulation in STAT3 GOF syndrome, showing partial normalization with JAK inhibitors.

The paper identifies a novel PIK3R1 frameshift mutation linked to immunodeficiency and ALS, showing haploinsufficiency causes neuronal dysfunction and apoptosis.

The paper identifies microbially-produced phospholipids that reduce inflammation and counteract antibiotic-induced type 1 diabetes in mice, with similar effects observed in humans.

This study identifies genetic changes in M. abscessus outbreak strains that lead to high imipenem resistance, suggesting carbapenem/{beta}-lactamase inhibitor combinations for treatment.

ImmunoTyper-SR genotypes IGHV alleles from short read data and identifies associations between IGHV alleles and anti-type I IFN autoantibodies in COVID-19 patients.

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.

ARZIMM infers microbial interactions and community stability from longitudinal microbiome data using a zero-inflated mixed-effects model.