Lisa R. Young

The paper constructs a single-cell atlas of PVOD across the lifespan, identifying endothelial dysfunction and molecular pathways as key drivers of the disease with potential therapeutic targets.

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

The paper identifies dynamic Hippo pathway activity in secondary crest myofibroblasts during lung alveolar development and shows its role in regulating lineage commitment and mesenchymal differentiation.

This study shows that BRD4 in endodermal cells is crucial for lung development by facilitating epithelial-mesenchymal crosstalk, proper lineage allocation, and branching morphogenesis.

The paper identifies a CXCL12 morphogen gradient in developing pulmonary vasculature, revealing endothelial heterogeneity and its role in vascular growth.