Sylvia N. Michki

The paper constructs a single-cell atlas of PVOD across the lifespan, identifying endothelial dysfunction and molecular pathways as key drivers of the disease with potential therapeutic targets.

This study identifies Stc1-expressing myofibroblasts as a distinct lineage that undergoes apoptosis during neonatal lung development, using genetic tools and single-cell RNA-seq.

This study investigates the spatiotemporal dynamics of primary and motile cilia during lung development, revealing distinct patterns in endothelial, epithelial, and mesenchymal cells.

The paper identifies dynamic Hippo pathway activity in secondary crest myofibroblasts during lung alveolar development and shows its role in regulating lineage commitment and mesenchymal differentiation.

This study shows that BRD4 in endodermal cells is crucial for lung development by facilitating epithelial-mesenchymal crosstalk, proper lineage allocation, and branching morphogenesis.

The paper identifies a CXCL12 morphogen gradient in developing pulmonary vasculature, revealing endothelial heterogeneity and its role in vascular growth.

nGauge provides an extensible Python toolkit for analyzing neuron morphology data, improving data compatibility and enabling advanced analysis and visualization.

The paper uses targeted scRNA-seq and multi-informatic analysis to characterize neural differentiation in Drosophila brain neuroblast lineages and provides a visualization tool for gene function curation.

This study introduces Lineage Tracker Bitbow, a multi-spectral lineage tracing system for Drosophila, and uses it to map neuronal lineages and analyze cis-regulatory elements in lineage-specific gene expression.