Joseph D. Planer

A postnatal human lung developmental atlas reveals windows of genetic vulnerability to chronic lung disease

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

Alveolar epithelium propagates mechanical signals that control multi-cellular homeostasis in the lung

This study shows that alveolar epithelial type I cells propagate mechanical signals that affect lung homeostasis and disease states through intercellular communication.

A longitudinal atlas of post-viral lung regeneration reveals persistent injury-associated cell states

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Hyperactive mTOR in Lung Mesenchyme Induces Endothelial Dysfunction and Pulmonary Vascular Remodeling

The paper investigates how hyperactive mTOR in lung mesenchyme leads to endothelial dysfunction and pulmonary vascular remodeling in LAM.