Pawel Grzechnik

This study shows that antisense oligonucleotides targeting transcription termination windows can decrease gene expression by disrupting mRNA 3' end processing and causing off-target effects.

The paper investigates the degradation mechanisms of non-capped mRNAs by depleting capping enzymes in yeast, revealing that Xrn1 buffers mRNA levels and protects against 5-3 degradation.

This study identifies RPRD proteins as negative regulators of transcription in human cells, showing their inverse correlation with RNA accumulation and their role in forming complexes with Pol II.

The paper investigates how non-coding RNAs from the Prader-Willi syndrome locus regulate gene expression in human iPSCs, showing their role in neurodevelopmental processes.