Jonathan Lee Yang

This study maps the human cell surface proteome at nanoscale resolution, identifying functional modules and spatial organization patterns in T-lymphocytes and B-lymphoblasts.

This paper develops GELYTACs, lysosome-targeting chimeras that deplete IgG in vivo via AAV delivery, showing sustained antibody depletion in mice.

The paper describes the development of genetically encodable LYTACs (GELYTACs) for targeted protein degradation using engineered T-cells, showing efficacy in secreting and delivering the therapeutics.